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Home >> Antibodies >> p-JNK Antibody (pT183/Y185)

p-JNK Antibody (pT183/Y185) (F48652)

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  Catalog No Formulation Size Price (USD)  
Image F48652-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 439
Image
F48652-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 205
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Dot blot analysis of p-JNK antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Dot blot analysis of p-JNK antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Rat, Xenopus
Format Antigen affinity purified
Host Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P45983
Applications Dot Blot : 1:500
Limitations This p-JNK antibody is available for research use only.
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Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Application Notes

Titration of the p-JNK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This p-JNK antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT183/Y185 of human JNK1.

Storage

Aliquot the p-JNK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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