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Home >> Antibodies >> p-JNK Antibody (pT183/Y185)

p-JNK Antibody (pT183/Y185) (F48652)

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  Catalog No Formulation Size Price (USD)  
Image F48652-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F48652-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Dot blot analysis of p-JNK antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Dot blot analysis of p-JNK antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Rat, Xenopus
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P45983
Applications Dot blot : 1:500
Limitations This p-JNK antibody is available for research use only.
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Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Application Notes

Titration of the p-JNK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This p-JNK antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT183/Y185 of human JNK1.

Storage

Aliquot the p-JNK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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