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Home >> Antibodies >> p-ErbB2 Antibody (pY1248)

p-ErbB2 Antibody (pY1248) (F48395)

  Catalog No Formulation Size Price (USD)  
Image F48395-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F48395-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of extracts from A431 cells, untreated or treated with EGF (100ng/ml), using p-ERBB2 antibody (left) or nonphos Ab (right)
Dot blot analysis of p-ErbB2-antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P04626
Applications Western blot : 1:8000
Dot blot : 1:500
Limitations This p-ErbB2 antibody is available for research use only.
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Description

ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

Application Notes

Titration of the p-ErbB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This p-ErbB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1248 of human HER2/ErbB2.

Storage

Aliquot the p-ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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