- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
OX2R Antibody / OX-2 receptor / CD200R1 [clone CD200R1/9919R] (V5863)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5863-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5863-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5863SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CD200R1/9919R |
| UniProt | Q8TD46 |
| Localization | Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This OX2R/OX-2 receptor antibody is available for research use only. |
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OX2R antibody targets OX-2 receptor, also known as CD200 receptor 1 (CD200R1), an immunoregulatory cell surface receptor that plays a key role in controlling immune activation and maintaining peripheral tolerance. OX-2 receptor is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily and is predominantly expressed on myeloid lineage cells, including macrophages, dendritic cells, and certain lymphocyte subsets. The receptor interacts with its ligand CD200 (OX-2), delivering inhibitory signals that dampen inflammatory and immune responses.
OX-2 receptor functions as an immune checkpoint molecule by suppressing excessive activation of innate and adaptive immune cells. Engagement of OX2R by CD200 leads to recruitment of intracellular adaptor proteins and downstream signaling pathways that limit pro-inflammatory cytokine production and cellular activation. This regulatory axis is essential for immune homeostasis, helping prevent tissue damage during immune responses while supporting tolerance to self-antigens.
OX2R antibody, also referred to as OX-2 receptor antibody and CD200 receptor 1 antibody in the literature, is commonly used in research settings to examine immune inhibitory pathways and cell surface receptor expression. OX-2 receptor has been studied extensively in the context of immune regulation, transplantation biology, tumor immune evasion, and neuroinflammation. Dysregulation of CD200-CD200R signaling has been associated with altered immune surveillance in cancer and chronic inflammatory conditions, highlighting its relevance in immunology research.
At the cellular level, OX-2 receptor is localized primarily to the plasma membrane, consistent with its role as a ligand-binding inhibitory receptor. Expression patterns vary depending on tissue type and immune cell activation state, with higher levels often observed in immune-rich environments. The receptor is encoded by the CD200R1 gene and is sometimes abbreviated as OX2R in immunology-focused studies and antibody catalogs. Clone CD200R1/9919R is designed to recognize OX-2 receptor for research applications requiring consistent target detection. In studies utilizing OX2R antibody, clone CD200R1/9919R has been incorporated as a molecular tool to support investigations into immune checkpoint signaling and receptor expression profiling.
OX-2 receptor is also referred to by several alternative names, including CD200R, CD200R1, and OX2R, reflecting its long-standing presence in immunological research. Because of its inhibitory function, OX2R antibody is frequently included in studies focused on immune modulation, myeloid cell biology, and mechanisms of immune suppression. Clone CD200R1/9919R provides a defined reagent option for researchers examining OX-2 receptor expression within these biological contexts.
1. Optimal dilution of the OX2R/OX-2 receptor antibody should be determined by the researcher.
2. This OX2R/OX-2 receptor antibody is recombinantly produced by expression in CHO cells.
A recombinant fragment (around amino acids 50-250) of human CD200R1 protein (exact sequence is proprietary) was used as the immunogen for the OX2R/OX-2 receptor antibody.
OX2R/OX-2 receptor antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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