OTT1 Antibody / RBM15 / One-twenty two protein 1 (RQ8057)

Description

OTT1 (One-twenty two protein 1), also called RBM15), is an RNA-binding protein involved in post-transcriptional gene regulation. It contains RNA recognition motifs and a SPOC domain that enable it to bind specific RNA sequences and interact with splicing and mRNA export machinery. OTT1 has been shown to influence alternative splicing, RNA stability, and nuclear export, and is also associated with components of the m⁶A RNA methylation machinery, contributing to epitranscriptomic regulation.

OTT1 plays roles in hematopoietic development and transcriptional control through its interactions with transcription factors and chromatin-associated complexes. It is expressed in various tissues, with enriched expression in early hematopoietic and embryonic cell populations, making it a useful marker in developmental and RNA processing studies.

The OTT1 antibody is a powerful tool for detecting endogenous RBM15 in applications such as western blot, immunofluorescence, and immunohistochemistry. Researchers use the OTT1 antibody from NSJ Bioreagents to monitor protein levels, assess subcellular localization, and explore RNA–protein interactions under various experimental conditions. With high specificity and consistent performance, the OTT1 antibody supports in-depth studies of RNA regulation, nuclear processes, and RNA-binding protein networks.

Application Notes

Optimal dilution of the OTT1 antibody should be determined by the researcher.

Immunogen

E. coli-derived recombinant human protein (amino acids M1-K967) was used as the immunogen for the OTT1 antibody.

Storage

After reconstitution, the OTT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.