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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
Researchers studying melanoma-associated antigens, cancer-testis antigen biology, and tumor-associated immune signaling pathways may also be interested in our PRAME Antibody / Tumor Immunology Marker page featuring validated immunohistochemistry and western blot applications for PRAME-associated cancer research.
Optimal dilution of the Opa-interacting Protein 4 Antibody / Tumor Antigen should be determined by the researcher.
A recombinant fragment (within amino acids 100-250) of human PRAME protein was used as the immunogen for the Opa-interacting protein 4 antibody.
Aliquot the PRAME antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PRAME antibody, OIP-4 antibody, Preferentially expressed antigen in melanoma antibody, Cancer-testis antigen antibody, Tumor immunology marker antibody
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