- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NUP160 Antibody / Nuclear pore complex protein Nup160 (FY12430)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12430 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
The NUP160 antibody targets Nuclear pore complex protein Nup160, a large scaffold protein encoded by the NUP160 gene. Nuclear pore complex protein Nup160 is an essential component of the Nup107160 subcomplex that forms the structural framework of the nuclear pore complex (NPC). This complex regulates bidirectional transport of macromolecules between the nucleus and cytoplasm, controlling RNA export, protein import, and cell-cycle progression. The NUP160 antibody provides researchers with a robust reagent for studying nucleocytoplasmic transport, nuclear envelope assembly, and the architecture of the NPC.
Nuclear pore complex protein Nup160 contributes to the assembly and stability of the Nup107160 complex, which includes Nup107, Nup133, Nup96, and Sec13. It localizes to both the cytoplasmic and nucleoplasmic faces of the nuclear envelope and interacts with importins, exportins, and Ran GTPase to regulate nuclear transport. The NUP160 antibody enables detection of this scaffold protein in isolated nuclei and cultured cells, revealing how changes in NPC composition affect molecular trafficking.
Beyond transport, Nuclear pore complex protein Nup160 plays key roles in mitosis. During cell division, the Nup107160 complex redistributes to kinetochores, where it assists in spindle assembly and chromosome segregation. The NUP160 antibody supports visualization of these dynamic localization patterns, helping clarify the interface between nuclear pore biology and mitotic regulation. Disruption of NUP160 expression or function leads to nuclear envelope defects, delayed cell-cycle progression, and genomic instability.
Mutations in NUP160 have been linked to steroid-resistant nephrotic syndrome and immune dysregulation, reflecting the importance of intact nuclear transport in tissue homeostasis. The NUP160 antibody is used in studies of nuclear porerelated diseases, including autoimmune and neurodegenerative conditions. Reduced expression or structural alteration of Nup160 can also influence viral nuclear import and cellular stress responses.
The NUP160 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, yielding strong nuclear envelope staining consistent with pore complex localization. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for use in cell biology, molecular genetics, and structural research. By enabling precise detection of Nuclear pore complex protein Nup160, the NUP160 antibody advances understanding of nuclear transport regulation, pore architecture, and the cellular responses governed by NPC function.
Optimal dilution of the NUP160 antibody should be determined by the researcher.
E.coli-derived human NUP160 recombinant protein (Position: E880-K1364) was used as the immunogen for the NUP160 antibody.
After reconstitution, the NUP160 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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