- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NRP2 Antibody (R30864)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R30864 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | O60462 |
| Applications | Western blot : 0.5-1ug/ml |
| Limitations | This NRP2 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Neuropilin-2, also called Npn2 or VEGF165R2, is a member of the neuropilin family of receptor proteins. Sema3b can act to repulse axons expressing neuropilin-2 and can antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1. NRP2 may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components NRP2 and Plexin A3 (PLEXA3) exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in NRP2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Neuropilin-2 to apical dendrites and of NRP1 to all dendrites of cortical pyramidal neurons.
The stated application concentrations are suggested starting amounts. Titration of the NRP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 45-60 (YPQDYPSHQNCEWIVY-human) were used as the immunogen for this NRP2 antibody (100% mouse homology).
After reconstitution, the NRP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz