- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NRG1 Antibody / ErbB Receptor Ligand Antibody (R31075)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31075 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q02297 |
| Localization | Cytoplasm, nucleus, membrane |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml |
| Limitations | This NRG1 Antibody / ErbB Receptor Ligand Antibody is available for research use only. |
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NRG1 Antibody / ErbB Receptor Ligand Antibody recognizes neuregulin-1, a multifunctional signaling protein encoded by the NRG1 gene. NRG1 belongs to the neuregulin family of epidermal growth factor-like ligands and is produced in numerous forms through alternative promoter usage and extensive alternative splicing. These isoforms differ in their N-terminal regions, EGF-like domains, membrane topology and processing, contributing to the diverse biological functions associated with neuregulin-1.
NRG1 proteins contain an EGF-like domain responsible for interaction with ErbB receptor tyrosine kinases. Neuregulin-1 binds directly to ErbB3 and ErbB4, promoting formation of receptor homo- or heterodimers that can include ErbB2. Activation of these receptor complexes regulates downstream pathways including PI3K-AKT and MAPK signaling. Through this signaling network, NRG1 influences cellular proliferation, survival, migration and differentiation.
Different NRG1 isoforms can function through soluble, paracrine or membrane-associated signaling mechanisms. Many forms are synthesized as membrane-anchored precursors that undergo proteolytic processing, while certain isoforms remain membrane tethered and mediate signaling between neighboring cells. NRG1-ErbB signaling has particularly important functions in nervous system development and Schwann cell biology and also contributes to cardiac development and homeostasis. Its broad biological activities have additionally made NRG1 relevant to research in cancer, neurobiology and developmental signaling.
This rabbit polyclonal antibody was generated against a C-terminal peptide of human neuregulin-1 and is antigen affinity purified. It recognizes human, mouse and rat NRG1 and has been validated using Western blot, immunohistochemistry and immunofluorescence. NSJ Bioreagents provides this NRG1 Antibody for research into neuregulin expression, developmental biology and receptor-mediated signaling. An ErbB Receptor Ligand Antibody can support investigation of the diverse NRG1 isoforms and their roles in cellular communication.
Explore our Signal Transduction Antibodies page for additional reagents targeting proteins involved in receptor activation, intracellular signaling and regulation of cellular responses.
The stated application concentrations are suggested starting amounts. Titration of the NRG1 Antibody / ErbB Receptor Ligand Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminus of human Neuregulin 1 (RFSTQEEIQARLSSVIANQD) was used as the immunogen for this NRG1 antibody.
After reconstitution, the NRG1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
NRG1 antibody, neuregulin-1 antibody, neuregulin 1 antibody, heregulin antibody, HRG antibody, neu differentiation factor antibody, NDF antibody, ARIA antibody
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