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Home >> Antibodies >> NRG1 Antibody

NRG1 Antibody (F52563)

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  Catalog No Formulation Size Price (USD)  
Image F52563-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F52563-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of lysate from RD cell line (human rhabdomyosarcoma) using NRG1 antibody at 1:1000. Predicted molecular weight of multiple isofoms: 26-70 kDa.
Western blot analysis of lysate from RD cell line (human rhabdomyosarcoma) using NRG1 antibody at 1:1000. Predicted molecular weight of multiple isofoms: 26-70 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q02297
Applications Western blot : 1:1000
Limitations This NRG1 antibody is available for research use only.
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Description

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Application Notes

Titration of the NRG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A peptide corresponding to the amino acids surrounding Q212 were used as the immunogen for this NRG1 antibody.

Storage

Aliquot the NRG1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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