- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NRF2 Antibody / Nuclear factor erythroid 2-related factor 2 / NFE2L2 (FY13169)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13169 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
NRF2 antibody detects Nuclear factor erythroid 2-related factor 2, a transcription factor that regulates antioxidant defense and cellular detoxification. The UniProt recommended name is Nuclear factor erythroid 2-related factor 2 (NFE2L2). This basic leucine zipper (bZIP) transcription factor activates expression of antioxidant response element (ARE)-driven genes that protect cells against oxidative and electrophilic stress.
Functionally, NRF2 antibody identifies a 605-amino-acid protein that binds to DNA as a heterodimer with small Maf proteins. Under basal conditions, NRF2 is bound by KEAP1 in the cytoplasm and targeted for proteasomal degradation. Upon oxidative stress, NRF2 escapes KEAP1 repression, translocates to the nucleus, and induces genes encoding detoxification enzymes, antioxidant proteins, and drug-metabolizing enzymes such as NQO1, HO-1, and GCLM.
The NFE2L2 gene is located on chromosome 2q31.2 and is expressed in multiple tissues, with high levels in liver, lung, and kidney. NRF2 acts as a master regulator of cellular defense mechanisms, maintaining redox balance, xenobiotic metabolism, and mitochondrial function.
Pathologically, persistent NRF2 activation contributes to tumorigenesis and drug resistance, while impaired NRF2 signaling increases susceptibility to oxidative injury and chronic diseases such as neurodegeneration and fibrosis. Research using NRF2 antibody supports studies in transcriptional regulation, redox signaling, and cytoprotection.
NRF2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect transcription factors involved in antioxidant defense. NSJ Bioreagents provides NRF2 antibody reagents optimized for oxidative stress, cancer, and metabolism research.
Structurally, Nuclear factor erythroid 2-related factor 2 contains multiple Neh (Nrf2-ECH homology) domains that mediate DNA binding, KEAP1 interaction, and transcriptional activation. This antibody aids investigation of NRF2s dynamic regulation and its role in cellular adaptation to stress.
Optimal dilution of the NRF2 antibody should be determined by the researcher.
E.coli-derived human NRF2/NFE2L2 recombinant protein (Position: E67-D601) was used as the immunogen for the NRF2 antibody.
After reconstitution, the NRF2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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