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Home >> Antibodies >> NRAS Antibody

NRAS Antibody [clone DBC-14] (RQ4865)

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Image RQ4865 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
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Western blot testing of 1) rat C6 and 2) human Jurkat cell lysate with NRAS antibody. Predicted molecular weight ~21 kDa.
Western blot testing of 1) rat C6 and 2) human Jurkat cell lysate with NRAS antibody. Predicted molecular weight ~21 kDa.
Availability 1-2 weeks
Species Reactivity Human, Rat
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name DBC-14
Purity Affinity purified
UniProt P01111
Applications Western blot : 1:10000-1:20000
Limitations This NRAS antibody is available for research use only.
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Description

NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. It has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in the gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [RefSeq]

Application Notes

Optimal dilution of the NRAS antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human NRAS was used as the immunogen for the NRAS antibody.

Storage

Store the NRAS antibody at -20oC.

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