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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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NR2C2 Antibody 31N37 recognizes nuclear receptor subfamily 2 group C member 2 (NR2C2), a transcription factor also known as testicular receptor 4 (TR4). This protein belongs to the nuclear receptor superfamily and functions as an orphan nuclear receptor, meaning that its physiological ligand has not been conclusively established. NR2C2 regulates gene expression through interactions with specific DNA response elements and transcriptional cofactors. Although originally associated with reproductive biology, TR4 participates in diverse processes involving metabolism, cellular differentiation, and development.
NR2C2 contains a conserved DNA-binding domain with two zinc finger motifs, a hinge region, and a C-terminal ligand-binding domain. These structural features enable the receptor to recognize regulatory DNA sequences and interact with proteins that influence transcription. Depending on the target gene and cellular environment, NR2C2 can function as either a transcriptional activator or repressor. Its regulatory activity involves interactions with coactivators, corepressors, and chromatin-associated proteins that influence the accessibility of target genes.
TR4 Monoclonal Antibody is relevant to investigations of metabolic regulation and nuclear receptor signaling. NR2C2 participates in transcriptional programs associated with glucose homeostasis, lipid metabolism, and energy balance. Through its interactions with other regulatory proteins, TR4 helps coordinate metabolic gene expression with physiological conditions. Its activity has also been linked to cellular stress responses, mitochondrial regulation, and mechanisms that maintain metabolic homeostasis.
In reproductive biology, NR2C2 contributes to testicular development, germ cell differentiation, and the regulation of genes involved in reproductive function. The receptor also participates in nervous system development, where it influences neuronal differentiation and transcriptional programs important for brain function. In cancer research, altered TR4 activity has been associated with changes in cell proliferation, differentiation, and tumor progression. These effects are context-dependent, reflecting the diverse transcriptional networks regulated by NR2C2 in different tissues.
NSJ Bioreagents provides NR2C2 Antibody 31N37 as a recombinant rabbit monoclonal reagent for investigating this orphan nuclear receptor. Recombinant monoclonal antibody production offers a defined antibody sequence and supports consistency between manufacturing batches. Research into NR2C2 continues to clarify how nuclear receptor signaling integrates developmental and metabolic signals with transcriptional regulation. An NR2C2 Antibody 31N37 can support studies of TR4-dependent gene regulation, reproductive biology, and metabolic signaling.
For additional NR2C2 research, explore our NR2C2 Antibody, a polyclonal antibody with WB, IHC, IF, and IP validation.
Optimal dilution of the NR2C2 Antibody 31N37 / TR4 Monoclonal Antibody should be determined by the researcher.
A synthesized peptide derived from human NR2C2 / TR4 was used as the immunogen for the NR2C2 Antibody 31N37.
Store the NR2C2 Antibody 31N37 at -20oC.
Testicular Receptor 4 antibody, Nuclear Receptor Subfamily 2 Group C Member 2 antibody, Nuclear Receptor TR4 antibody, Orphan Nuclear Receptor TR4 antibody, Testicular Nuclear Receptor 4 antibody
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