- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NR1H3 Antibody / Oxysterols receptor LXR-alpha (FY13156)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13156 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
NR1H3 antibody detects Oxysterols receptor LXR-alpha, a nuclear receptor that regulates lipid metabolism, inflammation, and cholesterol homeostasis. The UniProt recommended name is Oxysterols receptor LXR-alpha (NR1H3). This transcription factor belongs to the nuclear receptor superfamily and functions as a ligand-activated regulator controlling expression of genes involved in lipid transport and metabolism.
Functionally, NR1H3 antibody identifies a 447-amino-acid receptor that binds oxysterol ligands, including 24(S)-hydroxycholesterol and 27-hydroxycholesterol. Upon activation, NR1H3 forms heterodimers with RXR and binds to LXR response elements in target gene promoters, stimulating transcription of ABCA1, SREBP-1c, and APOE to promote cholesterol efflux and fatty acid synthesis.
The NR1H3 gene is located on chromosome 11p11.2 and is highly expressed in liver, macrophages, and intestine. Its activity coordinates lipid handling in hepatocytes and immune cells, maintaining systemic cholesterol balance and preventing lipid accumulation. NR1H3 also modulates inflammatory gene expression by antagonizing NF-kappaB signaling.
Pathologically, dysregulation of NR1H3 contributes to atherosclerosis, fatty liver disease, and metabolic syndrome. Genetic variants in NR1H3 have been associated with autoimmune and neuroinflammatory disorders, including multiple sclerosis. Research using NR1H3 antibody supports studies in lipid regulation, transcriptional control, and metabolic disease mechanisms.
NR1H3 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect nuclear receptors and transcription factors. NSJ Bioreagents provides NR1H3 antibody reagents optimized for lipid metabolism, endocrinology, and transcriptional research.
Structurally, Oxysterols receptor LXR-alpha contains a DNA-binding zinc finger domain and a ligand-binding domain that mediates dimerization and transcriptional activation. This antibody supports analysis of NR1H3s regulatory functions in cholesterol and lipid homeostasis.
Optimal dilution of the NR1H3 antibody should be determined by the researcher.
E.coli-derived human NR1H3 recombinant protein (Position: D11-R401) was used as the immunogen for the NR1H3 antibody.
After reconstitution, the NR1H3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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