- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NPY2R Antibody / Neuropeptide Y receptor type 2 (FY12847)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12847 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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NPY2R antibody detects Neuropeptide Y receptor type 2, a G protein-coupled receptor (GPCR) that mediates the effects of neuropeptide Y (NPY) and peptide YY (PYY) in regulating appetite, energy balance, and vascular tone. Encoded by the NPY2R gene on chromosome 4q31.3, this receptor belongs to the rhodopsin-like GPCR family and signals primarily through Gi/o proteins to inhibit adenylyl cyclase, reduce cyclic AMP production, and modulate calcium and potassium channel activity.
NPY2R is expressed in the central and peripheral nervous systems, particularly in hypothalamic nuclei involved in appetite control, as well as in adipose tissue, gastrointestinal tract, and cardiovascular system. Activation of NPY2R contributes to satiety signaling, vasoconstriction, and neuroendocrine secretion regulation. In neurons, NPY2R often acts as an autoreceptor, controlling presynaptic release of NPY and other neurotransmitters, thus fine-tuning synaptic transmission and energy homeostasis.
The NPY2R antibody is widely used in neuroscience, endocrinology, and metabolism research to investigate neuropeptide signaling, feeding behavior, and receptor pharmacology. Western blot analysis identifies a 43 kilodalton band corresponding to NPY2R, while immunohistochemistry reveals membrane-associated staining in hypothalamic neurons and vascular smooth muscle cells. This antibody supports studies examining receptor localization, ligand binding, and downstream signaling in physiological and pathological contexts.
At the molecular level, NPY2R activation influences pathways such as ERK1/2 and PI3K/AKT, affecting neuronal excitability and metabolic regulation. Altered NPY2R expression or function is linked to obesity, anxiety, hypertension, and gastrointestinal disorders. Pharmacological targeting of NPY2R offers therapeutic potential for appetite control and cardiovascular modulation. The NPY2R antibody provides a valuable tool for mapping receptor distribution and characterizing its role in neuroendocrine and metabolic signaling. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and immunofluorescence, ensuring reproducible detection across neural and peripheral systems.
Optimal dilution of the NPY2R antibody should be determined by the researcher.
E.coli-derived human NPY2R recombinant protein (Position: M1-K367) was used as the immunogen for the NPY2R antibody.
After reconstitution, the NPY2R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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