- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NOX4 Antibody / NADPH oxidase 4 [clone E-14] (RQ4482)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ4482 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 429 |
| Availability | 1-2 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | E-14 |
| Purity | Protein A affinity |
| UniProt | Q9NPH5 |
| Localization | Cytoplasm (ER membrane) |
| Applications | Western blot : 1:500-1:2000 Immunohistochemisty (FFPE) : 1:50-1:200 Immunofluorescence : 1:50-1:200 |
| Limitations | This NOX4 antibody is available for research use only. |
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Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [UniProt]
Optimal dilution of the NOX4 antibody should be determined by the researcher.
A synthetic peptide from human NOX4 was used as the immunogen for the NOX4 antibody.
Store the NOX4 antibody at -20oC.
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