- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NOLC1 Antibody / Nucleolar and coiled-body phosphoprotein 1 [clone 30N31] (FY12841)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12841 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
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NOLC1 antibody detects nucleolar and coiled-body phosphoprotein 1, encoded by the NOLC1 gene. This protein is also called NOPP140, nuclear phosphoprotein 140, and hNOPP140. NOLC1 is a nucleolar protein that shuttles between the nucleolus and cytoplasm, functioning as a phosphoprotein involved in ribosome biogenesis, rRNA transcription, and nucleolar organization. Structurally, NOLC1 contains multiple serine-rich regions that undergo phosphorylation, regulating its localization and interactions with RNA polymerase I and ribosomal proteins.
NOLC1 antibody is widely applied in cell biology, cancer research, and nucleolar studies. By detecting NOLC1, researchers can investigate how the nucleolus coordinates ribosome production and stress responses. The protein is highly expressed in proliferating cells, linking it to growth and transformation. Dysregulated NOLC1 expression has been reported in cancers, where nucleolar function is often enhanced to meet elevated translational demands.
Applications of NOLC1 antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blot assays detect phosphorylated and unphosphorylated isoforms, immunohistochemistry maps expression in tumors, and immunofluorescence highlights nucleolar localization and dynamics. These approaches provide powerful tools for studying nucleolar biology in health and disease.
NOLC1 interacts with RNA polymerase I transcription machinery, fibrillarin, and nucleolin, coordinating rRNA transcription and processing. It also functions in nucleolar stress responses, where its relocalization signals cellular stress or DNA damage. By applying NOLC1 antibody, scientists can study how nucleolar function integrates with signaling pathways in cancer, aging, and neurodegeneration.
NOLC1 mutations and expression changes contribute to oncogenesis. Overexpression correlates with tumor growth, while knockdown reduces proliferation. Because nucleolar size and activity are biomarkers of cancer, NOLC1 detection provides diagnostic and prognostic potential. NSJ Bioreagents offers NOLC1 antibody with validated specificity, ensuring reliable performance in nucleolar and cancer research.
Optimal dilution of the NOLC1 antibody should be determined by the researcher.
A synthesized peptide derived from human NOLC1 was used as the immunogen for the NOLC1 antibody.
Store the NOLC1 antibody at -20oC.
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