- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NM23 Antibody / Metastasis Suppressor Protein Antibody [clone NME1/2738] (V9511)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9511-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9511-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9511SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | NME1/2738 |
| Purity | Protein A/G affinity |
| UniProt | P15531 |
| Localization | Nucleus, Cytoplasm |
| Applications | ELISA (order BSA-free Format For Coating) : Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This NM23 Antibody / Metastasis Suppressor Protein Antibody is available for research use only. |
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NM23 Antibody / Metastasis Suppressor Protein Antibody detects NME1, a multifunctional protein historically known as NM23-H1 and encoded by the NME1 gene. NME1 functions as nucleoside diphosphate kinase A, an enzyme involved in maintaining cellular nucleotide pools through phosphate transfer between nucleoside di- and triphosphates. NM23-H1 has also been extensively investigated in cancer biology because of its association with suppression of metastatic behavior, making NME1 relevant to studies of both cellular metabolism and tumor progression.
NM23 was originally identified through comparisons of murine melanoma cell lines exhibiting different metastatic capacities. Lower NM23 expression was observed in highly metastatic cells, leading to the identification of NME1 as an early metastasis suppressor gene. Subsequent research has examined its involvement in cell migration, invasion, adhesion and other processes contributing to metastatic progression. The relationship between NME1 expression and tumor behavior can vary among cancer types and biological contexts, but metastasis suppression remains a major area of NM23-H1 research.
NME1 belongs to the NME/NM23 family of nucleoside diphosphate kinases. Human NME1 and the closely related NME2 correspond to the historically designated NM23-H1 and NM23-H2 proteins, respectively. NME1 encodes nucleoside diphosphate kinase A, whereas NME2 encodes the B isoform. These proteins participate in nucleotide homeostasis and can form oligomeric complexes, linking their enzymatic functions with broader cellular processes involving proliferation, differentiation and signaling.
Research on NM23-H1 extends beyond its original identification as a metastasis suppressor. NME1 has been investigated in cellular differentiation, development, DNA-associated processes and regulatory networks affecting cell behavior. Its combination of nucleoside diphosphate kinase activity and cancer-associated functions makes NM23 an important research target for examining relationships among nucleotide metabolism, signaling and mechanisms controlling tumor progression.
Clone NME1/2738 is a mouse monoclonal antibody generated against recombinant full-length human NME1 protein and has been evaluated by Western blot and immunohistochemistry. It is also Protein Microarray Validated using a HuProt array containing more than 19,000 full-length human proteins. The Z-score measures target signal strength in standard deviations above the array mean, while the S-score measures separation between the intended target and the next strongest signal, providing an assessment of relative target specificity. NSJ Bioreagents supplies antibodies for cancer, metabolism and cell biology research. An NM23 Antibody can be used to investigate NME1 expression, metastasis suppression, nucleoside diphosphate kinase A biology and mechanisms associated with tumor progression.
For additional research on NME1 expression, nucleotide metabolism and metastasis-associated biology, see our NME1 Antibody / Nucleoside Diphosphate Kinase A Antibody page.
Optimal dilution of the NM23 Antibody / Metastasis Suppressor Protein Antibody should be determined by the researcher.
Recombinant full-length human NME1 protein was used as the immunogen for the NM23 antibody.
Aliquot the NM23 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
NM23 antibody, Metastasis Suppressor Protein antibody, NME1 antibody, NM23-H1 antibody, Nucleoside Diphosphate Kinase A antibody, NDPK-A antibody
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![Western blot testing of A549 [A] and HeLa [B] lysates with NME1 antibody at 0.01ug/ml. Predicted molecular weight: ~20/17kDa (isoforms a/b).](https://www.nsjbio.com/plp/thumb_image/img-R33690-100UG-1.jpg?v=1789543554 "Western blot testing of A549 [A] and HeLa [B] lysates with NME1 antibody at 0.01ug/ml. Predicted molecular weight: ~20/17kDa (isoforms a/b).")
