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- Tel: 858.663.9055
- Email: info@nsjbio.com
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).
Titration of the NLRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 121-149 from the human protein was used as the immunogen for this NLRP4 antibody.
Aliquot the NLRP4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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