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Home >> Antibodies >> NKX2.1 Antibody / TTF-1

NKX2.1 Antibody / TTF-1 [clone TTF1/8143R] (V4347)

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  Catalog No Formulation Size Price (USD)  
Image V4347-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4347-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4347SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human lung tissue with NKX2.1 antibody (clone TTF1/8143R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human lung tissue with NKX2.1 antibody (clone TTF1/8143R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name TTF1/8143R
Purity Protein A/G affinity
UniProt P43699
Localization Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This NKX2.1 antibody is available for research use only.
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Description

Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Application Notes

Optimal dilution of the NKX2.1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 1-400) from the human protein was used as the immunogen for the NKX2.1 antibody.

Storage

Aliquot the NKX2.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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