- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Nk1.1 Antibody / Cd161c [clone PK136] (V8986)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8986-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V8986-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
|
V8986SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Mouse |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | PK136 |
| Purity | Protein A/G affinity |
| UniProt | P27814 |
| Localization | Cell Surface |
| Applications | Flow Cytometry : 0.5-1ug/million cells in 0.1ml |
| Limitations | This Nk1.1 antibody is available for research use only. |
|
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|
Nk1.1 antibody detects the NK1.1 antigen, also known as Klrb1c, encoded by the KLRB1C gene in certain mouse strains. NK1.1 is a type II transmembrane receptor expressed on natural killer (NK) cells and subsets of T cells, where it participates in immune regulation and cytotoxic responses. Because NK1.1 expression is strain-specific and serves as a hallmark marker for NK cell identification in C57BL/6 and related mice, Nk1.1 antibody is widely used in immunology, oncology, and infectious disease research.
NK1.1 belongs to the C-type lectin-like receptor family and functions in immune recognition and regulation. Its expression provides a reliable surface marker for monitoring NK cell biology in experimental mouse models. Beyond NK cells, NK1.1 is also expressed on subsets of NKT cells, where it contributes to the regulation of cytokine responses and innate-adaptive immune crosstalk. This makes NK1.1 detection a valuable tool in studies of immunosurveillance and tumor immunity.
The Nk1.1 antibody clone PK136 has been widely cited in peer-reviewed studies of NK cell development, immune homeostasis, and antitumor immunity. Clone PK136 provides robust and reproducible detection, making it the standard for identifying NK cells in mouse models. Its applications include flow cytometry, cytotoxicity assays, and immunohistochemistry.
Research using clone PK136 has demonstrated how NK1.1 expression defines NK and NKT subsets involved in viral defense, tumor rejection, and autoimmune regulation. In oncology, detection with this antibody has clarified how NK cells infiltrate tumors and contribute to immune surveillance. In infectious disease, NK1.1 detection has been used to monitor NK cell responses to viral and bacterial pathogens. Its reproducibility ensures reliability across a wide range of immunological contexts.
NSJ Bioreagents provides this Nk1.1 antibody to support immunology, oncology, and infectious disease studies. Alternate designations include KLRB1C antibody, natural killer cell marker antibody, NK cell type II transmembrane receptor antibody, NKR-P1C antibody, and NK lineage surface antigen antibody.
Optimal dilution of the Nk1.1 antibody should be determined by the researcher.
Mouse spleen and bone marrow cells enriched for NK-1+ cells were used as the immunogen for the Nk1.1 antibody.
Aliquot the Nk1.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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