- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Neutrophil Elastase Antibody [clone AOCI-5] (RQ5209)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5209 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | AOCI-5 |
| Purity | Affinity purified |
| UniProt | P08246 |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This Neutrophil Elastase antibody is available for research use only. |
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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. [RefSeq]
Optimal dilution of the Neutrophil Elastase antibody should be determined by the researcher.
A synthetic peptide specific to human Neutrophil Elastase / ELANE was used as the immunogen for the Neutrophil Elastase antibody.
Store the Neutrophil Elastase antibody at -20oC.
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