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Home >> Antibodies >> Neurocan Antibody

Neurocan Antibody (R32974)

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  Catalog No Formulation Size Price (USD)  
Image R32974 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot tesing of rat 1) brain and 2) testis lysate with Neurocan antibody at 0.5ug/ml. Predicted molecular weight ~143 kDa (unmodified), up to ~250 kDa (fully glycosylated).
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Western blot tesing of rat 1) brain and 2) testis lysate with Neurocan antibody at 0.5ug/ml. Predicted molecular weight ~143 kDa (unmodified), up to ~250 kDa (fully glycosylated).
IHC testing of FFPE human glioma tissue with Neurocan antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
IHC testing of FFPE mouse brain tissue with Neurocan antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
UniProt O14594
Localization Secreted
Applications Western Blot : 0.5-1ug/ml
IHC (FFPE) : 1-2ug/ml
Limitations This Neurocan antibody is available for research use only.
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  • Applications : WB, Direct ELISA
    Reactivity : Human, Mouse, Rat

Description

Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.

Application Notes

Optimal dilution of the Neurocan antibody should be determined by the researcher.

Immunogen

Amino acids HENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFA were used as the immunogen for the Neurocan antibody.

Storage

After reconstitution, the Neurocan antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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