- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NELFB Antibody / Negative elongation factor B / COBRA1 [clone 32C80] (FY12017)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12017 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. | 100 ul | 439 |
| Availability | 2-3 weeks |
| Species Reactivity | Human |
| Format | Liquid |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 32C80 |
| Purity | Affinity-chromatography |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| UniProt | Q8WX92 |
| Applications | Western Blot : 1:500-1:2000 Immunohistochemistry : 1:50-1:200 Immunocytochemistry/Immunofluorescence : 1:50-1:200 |
| Limitations | This NELFB antibody is available for research use only. |
|
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NELFB antibody targets negative elongation factor B, also known as COBRA1, a transcriptional regulator involved in RNA polymerase II pausing. NELFB functions as part of the NELF complex, which includes NELFA, NELFC/D, and NELFE subunits. This complex stabilizes paused RNA polymerase II at promoter-proximal regions, ensuring proper regulation of transcriptional elongation. By fine-tuning transcription, NELFB contributes to developmental programs and cellular stress responses.
Studies with NELFB antibody have implicated the protein in cancer biology and hormone signaling. COBRA1 was first identified as a BRCA1-associated factor, and disruption of NELFB function has been linked to breast cancer progression and altered estrogen receptor activity. Beyond cancer, NELFB also regulates genes involved in embryonic development and immune responses, making it a versatile factor for gene expression studies.
Validated antibody clones for NELFB detection work in assays such as western blot, chromatin immunoprecipitation, and immunohistochemistry. These reagents enable researchers to study promoter-proximal pausing, transcriptional control, and protein-protein interactions within the NELF complex. Clone validation ensures specificity for NELFB rather than closely related transcriptional regulators.
NSJ Bioreagents supplies this NELFB antibody for studies in transcription regulation, cancer pathways, and developmental biology. Alternate names include negative elongation factor B antibody, COBRA1 antibody, and cofactor of BRCA1 antibody.
Optimal dilution of the NELFB antibody should be determined by the researcher.
A synthesized peptide derived from human NELFB was used as the immunogen for the NELFB antibody.
Store the NELFB antibody at -20oC.
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