- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NEAS Antibody / SPTAN1 / Alpha II Spectrin / Alpha Fodrin (RQ6726)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6726 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q13813 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence (FFPE) : 5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This NEAS antibody is available for research use only. |
|
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NEAS antibody recognizes Spectrin alpha chain, non-erythrocytic 1, also referred to as Alpha-II spectrin antibody and SPTAN1 antibody, a cytoskeletal protein that belongs to the spectrin family. SPTAN1 encodes a widely expressed actin-binding protein localized primarily to the cytoplasm and inner surface of the plasma membrane, where it forms heterodimers with beta spectrin to create a submembranous cytoskeletal network. NEAS Antibody | SPTAN1 targets this structural scaffolding protein for research applications investigating cytoskeletal organization and membrane stability.
Spectrin alpha chain, non-erythrocytic 1 plays a crucial role in maintaining cell shape, membrane integrity, and mechanical resilience. By forming tetrameric spectrin complexes, SPTAN1 links membrane proteins to the actin cytoskeleton, supporting membrane protein distribution and signal transduction. This protein is especially important in neurons, where it contributes to axonal stability, synaptic organization, and cytoskeletal dynamics. It is also expressed in epithelial and other non-erythroid tissues, consistent with its designation as non-erythrocytic spectrin.
SPTAN1 participates in multiple signaling pathways through interactions with ion channels, adhesion molecules, and signaling adaptors. Proteolytic cleavage of alpha-II spectrin by calpains and caspases occurs during apoptosis and neuronal injury, generating characteristic breakdown products that are widely studied in neurobiology and brain injury research. Because of these cleavage events, SPTAN1 is frequently investigated as a marker of cytoskeletal disruption and cellular damage.
The SPTAN1 gene is located on chromosome 9q33.2 and produces a large multidomain protein containing spectrin repeats that mediate dimerization and actin binding. Mutations in SPTAN1 have been associated with neurodevelopmental disorders, including epileptic encephalopathy and other neurological syndromes, highlighting its importance in neuronal development and stability. Altered spectrin organization has also been linked to cancer cell motility and metastasis, further expanding the relevance of this protein in disease biology.
NEAS antibody enables detection of SPTAN1 expression in diverse experimental systems. By targeting Spectrin alpha chain, non-erythrocytic 1, this antibody supports studies of cytoskeletal architecture, membrane organization, neuronal injury, apoptosis, and spectrin-mediated signaling pathways.
Optimal dilution of the NEAS antibody should be determined by the researcher.
Recombinant human protein (amino acids E1916-S2472) was used as the immunogen for the NEAS antibody.
After reconstitution, the NEAS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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