- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NDUFS2 Antibody / NADH dehydrogenase ubiquinone iron-sulfur protein 2 [clone 30N44] (FY12621)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12621 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
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NDUFS2 antibody detects NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, a mitochondrial respiratory chain complex I subunit encoded by the NDUFS2 gene. NDUFS2 is a core catalytic component of complex I, the largest enzyme of the oxidative phosphorylation system. It contains conserved iron-sulfur clusters that mediate electron transfer from NADH to ubiquinone. By supporting this process, NDUFS2 contributes to ATP generation and cellular energy metabolism.
NDUFS2 antibody is widely applied in mitochondrial biology, bioenergetics, and disease research. Complex I dysfunction is a hallmark of mitochondrial disorders, neurodegeneration, and metabolic disease. Detection of NDUFS2 provides a marker for complex I assembly and activity. By monitoring NDUFS2 expression, researchers can study mechanisms underlying mitochondrial dysfunction in conditions such as Leigh syndrome, Parkinson disease, and ischemia reperfusion injury.
The antibody is validated for western blotting, immunohistochemistry, and immunofluorescence. Western blot assays detect NDUFS2 protein in mitochondrial fractions, while immunohistochemistry highlights expression in metabolically active tissues such as heart, brain, and muscle. Immunofluorescence reveals punctate mitochondrial staining consistent with its inner membrane localization. These applications allow comprehensive analysis of complex I structure and function.
Mutations in NDUFS2 cause severe mitochondrial disease characterized by impaired energy metabolism, developmental delay, and neurodegeneration. By applying NDUFS2 antibody, scientists can investigate the molecular basis of these disorders and evaluate therapeutic strategies aimed at restoring complex I activity.
Beyond rare genetic disease, NDUFS2 plays roles in hypoxic adaptation, aging, and cancer metabolism. Changes in NDUFS2 expression affect reactive oxygen species production and signaling, linking mitochondrial function to cellular stress responses. The antibody therefore provides a valuable reagent for broad applications in mitochondrial research.
NDUFS2 antibody from NSJ Bioreagents offers strong specificity for detecting this essential complex I subunit, supporting reliable studies of oxidative phosphorylation and disease pathogenesis.
Optimal dilution of the NDUFS2 antibody should be determined by the researcher.
A synthesized peptide derived from human NDUFS2 was used as the immunogen for the NDUFS2 antibody.
Store the NDUFS2 antibody at -20oC.
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