- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
NDKB antibody recognizes Nucleoside diphosphate kinase B, a ubiquitously expressed enzyme encoded by the human NME2 gene that is essential for maintaining intracellular nucleotide balance. NDKB antibody detects a cytoplasmic and nuclear protein that catalyzes the reversible transfer of gamma-phosphates between nucleoside triphosphates and diphosphates, supporting cellular pools of ATP, GTP, CTP, and UTP required for DNA replication, RNA transcription, and signal transduction. Through this phosphotransfer activity, NDKB contributes to energy metabolism and nucleotide homeostasis across diverse cell types.
NDKB antibody, also referred to as NME2 antibody and nm23-H2 antibody in the literature, targets a member of the NME family of nucleoside diphosphate kinases. The protein assembles into a functional hexamer and contains a conserved histidine residue within its catalytic site that becomes transiently phosphorylated during enzymatic activity. This conserved structural architecture allows NDKB to regulate GTP-dependent signaling processes, including those involving small GTPases.
The NME2 gene is located on chromosome 17q21.3 and is closely related to NME1, another member of the metastasis-associated nm23 gene family. Beyond its enzymatic function, NDKB has been implicated in transcriptional regulation and protein-protein interactions that influence cell proliferation and differentiation. Its role in modulating signaling cascades extends its biological relevance beyond nucleotide metabolism alone.
Altered expression of NME family proteins has been described in several malignancies, where changes in expression may correlate with tumor progression or metastatic behavior depending on tumor type. Because NDKB participates in pathways influencing cytoskeletal organization, vesicle trafficking, and receptor-mediated signaling, it has been investigated in cancer research and cell motility studies.
NDKB expression is widespread in normal tissues, reflecting its fundamental metabolic role. Its consistent cytoplasmic distribution, with occasional nuclear localization, makes NDKB antibody useful for examining nucleotide metabolism and regulatory signaling pathways in both normal and transformed cells.
Clone NME2/6437 is a monoclonal antibody developed to target NDKB protein in research applications. An antibody to NDKB is suitable for detecting Nucleoside diphosphate kinase B expression and for studying cellular metabolism and signaling regulation in relevant experimental systems.
Optimal dilution of the NDKB antibody should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the NDKB antibody.
Aliquot the NDKB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.