- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NCAD Antibody / N-Cadherin / CDH2 [clone CDH2/8815R] (V4566)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4566-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4566-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4566SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat, Hamster, Rabbit, Guinea pig |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CDH2/8815R |
| Purity | Protein A/G affinity |
| UniProt | P19022 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT (Human) Western Blot : 2-4ug/ml (Human/Mouse/Rat/Hamster/Rabbit/Guinea pig) |
| Limitations | This NCAD antibody is available for research use only. |
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N-Cadherin (CDH2), commonly referred to as NCAD, is a classical calcium-dependent cell adhesion protein that plays a central role in maintaining structural integrity in both neural and cardiac tissues. N-Cadherin (CDH2) is a single-pass transmembrane glycoprotein localized at the plasma membrane, where it forms adherens junctions through homophilic interactions and anchors to the actin cytoskeleton via catenin family proteins. The NCAD Antibody / N-Cadherin Neural and Cardiac Adhesion Protein Antibody is designed to detect this essential adhesion molecule, which is highly enriched in tissues that require coordinated mechanical stability and intercellular communication.
NCAD antibody, also referred to as N-Cadherin antibody and CDH2 antibody in the literature, recognizes a protein that functions as a core mediator of cell-cell adhesion in both the nervous system and the heart. In neural tissue, N-Cadherin is critical for neuronal migration, neurite outgrowth, synapse formation, and stabilization of neural circuits. In cardiac tissue, it is a defining component of intercalated discs, where it maintains tight coupling between cardiomyocytes and supports synchronized contraction. These roles establish NCAD as a central adhesion protein linking structural organization with functional coordination in highly specialized tissues.
Structurally, N-Cadherin contains five extracellular cadherin repeat domains responsible for calcium-dependent adhesion, a single transmembrane region, and a conserved intracellular domain that binds beta-catenin and p120-catenin to stabilize adherens junctions and regulate intracellular signaling. This conserved architecture supports strong and dynamic cell-cell interactions while also enabling signal transduction pathways that influence cell behavior. N-Cadherin is also glycosylated, resulting in a slightly higher apparent molecular weight on SDS-PAGE than predicted, a reproducible feature observed in brain and heart tissue lysates.
Expression of NCAD is characteristically high in brain and heart tissues, as demonstrated by robust detection in both neural and cardiac lysates. This pattern reflects the fundamental requirement for N-Cadherin in tissues that experience continuous mechanical stress or require precise cellular connectivity. In the brain, this supports synaptic plasticity and network stability, while in the heart it preserves structural cohesion during repeated cycles of contraction. The strong expression observed across these tissue types reinforces the role of NCAD as a key adhesion molecule in maintaining tissue integrity under both dynamic and stable conditions.
Beyond its role in normal physiology, N-Cadherin is implicated in a range of disease processes. Increased NCAD expression is associated with epithelial-to-mesenchymal transition in cancer, where it contributes to enhanced cellular motility and invasive potential. In cardiovascular disease, altered N-Cadherin function can disrupt intercellular junctions and compromise myocardial structure. These associations highlight the importance of NCAD as both a structural protein and a regulator of cellular behavior in pathological contexts.
Clone CDH2/8815R is designed to recognize N-Cadherin with strong and reproducible detection in brain and heart tissues, supporting its use in studies focused on neural and cardiac adhesion biology. The combination of clear western blot detection and biologically relevant expression patterns makes this NCAD antibody particularly useful for investigating adherens junctions, intercellular connectivity, and adhesion-dependent signaling pathways in both normal and disease models.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the NCAD antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 605-905) from the human protein was used as the immunogen for the NCAD antibody.
Aliquot the NCAD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
N-Cadherin antibody, CDH2 antibody, Cadherin 2 antibody, NCAD WB antibody, N-Cadherin adhesion antibody
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