- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Myeloperoxidase Antibody / MPO (RQ7843)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7843 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P05164 |
| Applications | Western Blot : 0.5-1ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This Myeloperoxidase antibody is available for research use only. |
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Myeloperoxidase (MPO) is a heme-containing enzyme predominantly expressed in neutrophils and, to a lesser extent, in monocytes. It is stored in azurophilic granules and released during degranulation to support the innate immune response. MPO catalyzes the conversion of hydrogen peroxide and chloride ions into hypochlorous acid, a potent antimicrobial oxidant that contributes to pathogen clearance. Researchers frequently use a Myeloperoxidase antibody to investigate innate immunity, inflammation, and host defense mechanisms.
While MPO plays a critical role in antimicrobial activity, excessive or dysregulated production of hypochlorous acid can lead to oxidative stress and tissue damage. Elevated MPO activity has been linked to chronic inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. Employing a Myeloperoxidase antibody allows scientists to assess protein expression and localization in both normal immune responses and pathological inflammation.
MPO is also studied as a biomarker for cardiovascular disease, since increased circulating levels correlate with vascular injury and plaque instability. Beyond cardiovascular research, it has been implicated in neurodegeneration and cancer, where oxidative stress contributes to disease progression. Using a Myeloperoxidase antibody provides a reliable means of studying MPOâs dual role as both a protective antimicrobial enzyme and a potential driver of tissue injury.
NSJ Bioreagents offers a high-quality Myeloperoxidase antibody validated for applications including western blot, immunohistochemistry, and flow cytometry. Selecting a Myeloperoxidase antibody from NSJ Bioreagents ensures consistent detection and reproducible results in studies of immunity, inflammation, and disease pathology.
Optimal dilution of the Myeloperoxidase antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids K556-I697) was used as the immunogen for the Myeloperoxidase antibody.
After reconstitution, the Myeloperoxidase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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