- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MX1 Antibody / MxA / Myxovirus resistance protein 1 (FY13028)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13028 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
Related Products
|
MX1 antibody detects Myxovirus resistance protein 1, a dynamin-like GTPase that mediates antiviral defense against a wide range of RNA and DNA viruses. The UniProt recommended name is Interferon-induced GTP-binding protein Mx1 (MX1). Also known as MxA in humans, this protein is one of the best-characterized interferon-stimulated genes (ISGs) and represents a central effector of type I and type III interferon antiviral activity.
Functionally, MX1 antibody identifies a 662-amino-acid cytoplasmic GTPase that self-assembles into oligomeric rings and tubular structures upon activation. MX1 binds and traps viral nucleocapsids and replication complexes, blocking viral genome transcription and replication. Its antiviral spectrum includes orthomyxoviruses (such as influenza A), paramyxoviruses, bunyaviruses, and other RNA viruses, as well as certain DNA viruses. MX1 activity is GTP-dependent and requires oligomerization for full antiviral efficacy.
The MX1 gene is located on chromosome 21q22.3 and is transcriptionally induced by type I interferons (IFN-alpha and IFN-beta) and type III interferons (IFN-lambda). MX1 localizes to the cytoplasm and associates with intracellular membranes where viral replication occurs. Upon interferon stimulation, MX1 accumulates rapidly and remains active for several hours, providing a robust first-line defense during viral infection. Its antiviral mechanism includes sequestering viral nucleoproteins, blocking uncoating, and preventing the assembly of viral polymerase complexes.
In immunology, MX1 serves as a molecular signature of interferon pathway activation and is frequently used as a biomarker for assessing antiviral or autoimmune responses. Elevated MX1 expression is characteristic of viral infections, systemic lupus erythematosus, and interferonopathies. In contrast, genetic polymorphisms affecting MX1 activity can reduce viral resistance and modulate disease susceptibility. MX1 also contributes to innate immunity in epithelial barriers, liver, and lung tissues, providing localized protection against viral entry and replication.
MX1 antibody is widely used in virology, immunology, and interferon signaling research. It is suitable for western blotting, immunofluorescence, and immunohistochemistry to detect MX1 expression following viral infection or interferon treatment. This antibody enables monitoring of innate immune activation and evaluation of interferon pathway modulators. In pathology, MX1 staining is used to confirm interferon signature activation in autoimmune and inflammatory diseases.
Structurally, MX1 belongs to the dynamin superfamily of large GTPases, with conserved GTP-binding, stalk, and oligomerization domains. The protein hydrolyzes GTP to induce conformational changes required for viral entrapment. NSJ Bioreagents provides MX1 antibody reagents validated for use in antiviral signaling, innate immunity, and interferon response research.
Optimal dilution of the MX1 antibody should be determined by the researcher.
E.coli-derived human MX1 recombinant protein (Position: E315G-662) was used as the immunogen for the MX1 antibody.
After reconstitution, the MX1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz