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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MVP Antibody for WB / Major Vault Protein Western Blot Antibody (RQ4254)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ4254 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| UniProt | Q14764 |
| Localization | Cytoplasmic, nuclear |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml Flow Cytometry : 1-3ug/10^6 cells Immunofluorescence/Immunocytochemistry (FFPE) : 2-4ug/ml Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This MVP Antibody for WB / Major Vault Protein Western Blot Antibody is available for research use only. |
|
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Major Vault Protein (MVP), encoded by the MVP gene, is the principal structural component of vault ribonucleoprotein particles, large cytoplasmic complexes involved in intracellular transport, signal transduction, and cellular stress responses. MVP is also widely known as Lung resistance-related protein (LRP), and is frequently studied as a biomarker of multidrug resistance in cancer. MVP is broadly expressed across tissues, with particularly high levels in epithelial cells, immune populations, and tumor cells exhibiting therapy-resistant phenotypes.
MVP Antibody for WB, also referred to as Major vault protein western blot antibody or LRP antibody for western blot in the literature, is specifically designed for detecting MVP protein in denatured lysates with size resolution and quantitative comparison. This MVP Antibody for WB / Major Vault Protein Western Blot Antibody is uniquely positioned for experiments requiring clear band identification, relative expression analysis, and comparison across treatment conditions, making it well suited for studies of chemoresistance, cellular stress, and signaling pathway modulation. As a rabbit polyclonal antibody, it provides multi-epitope recognition, which supports strong signal detection even in complex or partially degraded samples.
In western blot applications, MVP is typically detected as a prominent high molecular weight band corresponding to its role as the dominant vault complex component. Depending on experimental conditions, additional bands may be observed due to post-translational modifications, partial processing, or association with vault complex components. These migration patterns are particularly relevant when analyzing samples subjected to drug treatment, oxidative stress, or signaling pathway activation, where MVP expression and modification state may change dynamically.
A Major vault protein western blot antibody is especially valuable for comparing MVP expression between drug-sensitive and drug-resistant cell lines. Elevated MVP levels are consistently associated with reduced intracellular drug accumulation, altered apoptotic signaling, and enhanced survival under chemotherapeutic stress. Western blot analysis provides a direct method to quantify these differences, enabling researchers to correlate MVP expression with resistance phenotypes and treatment response.
Beyond its role in drug resistance, MVP participates in signaling pathways such as PI3K-AKT and has been linked to regulation of apoptosis, autophagy, and cellular stress adaptation. Changes in MVP expression detected by western blot can therefore reflect broader alterations in cell survival pathways. This makes MVP antibody for WB particularly useful in mechanistic studies investigating how cells respond to environmental stress, immune signaling, or therapeutic intervention.
The MVP gene is located on chromosome 16p11.2 and encodes a protein composed of repeating structural domains that assemble into the characteristic barrel-shaped vault particle. While MVP is predominantly cytoplasmic, its interactions with signaling proteins and potential involvement in nucleocytoplasmic transport highlight its functional complexity. Western blot analysis enables consistent detection of MVP across diverse sample types, supporting reproducible evaluation of its expression and regulation.
This Major vault protein western blot antibody is suitable for detecting MVP expression in cell and tissue lysates, providing a reliable tool for studies of drug resistance, intracellular transport, and signaling pathway regulation where precise protein detection is required.
This MVP antibody is part of a broader collection of research tools designed to support studies in cancer biology, intracellular transport, and drug resistance mechanisms.
Optimal dilution of the MVP Antibody for WB / Major Vault Protein Western Blot Antibody should be determined by the researcher.
A recombinant human protein corresponding to amino acids A2-H259 was used as the immunogen for the MVP antibody.
After reconstitution, the MVP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Major vault protein western blot antibody, Lung resistance-related protein western blot antibody, LRP antibody for western blot, MVP antibody for WB, Vault protein western blot antibody
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