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Home >> Antibodies >> MVK Antibody / Mevalonate kinase

MVK Antibody / Mevalonate kinase [clone 28M97] (RQ8833)

  Catalog No Formulation Size Price (USD)  
Image RQ8833 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 439
Microvalidated Recrabbitmono
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Western blot testing of human HepG2 cell lysate with MVK antibody. Predicted molecular weight ~42 kDa.
Availability 1-3 days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name 28M97
Purity Affinity chromatography
UniProt Q03426
Applications Western Blot : 1:500-1:2000
Flow Cytometry : 1:50
Limitations This MVK antibody is available for research use only.
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Description

MVK is an enzyme that catalyzes the conversion of mevalonate, a key compound in the biosynthesis of cholesterol, into mevalonate-5-phosphate. This reaction is a crucial step in the mevalonate pathway, which ultimately leads to the production of important molecules such as cholesterol, steroid hormones, and certain vitamins. Deficiencies in MVK have been linked to a rare genetic disorder known as Mevalonate kinase deficiency (MKD). This condition is characterized by recurrent fevers, inflammation, and other health problems. Recent research has also shed light on the potential role of MVK in cancer development. Studies have shown that MVK may play a role in regulating cell growth and proliferation, making it a potential target for anti-cancer therapies.

Application Notes

Optimal dilution of the MVK antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human Mevalonate kinase was used as the immunogen for the MVK Antibody.

Storage

Store the MVK antibody at -20oC.

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