- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MutS homolog 2 Antibody / MSH2 [clone MSH2/3165] (V4892)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4892-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4892-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4892SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2, kappa |
| Clone Name | MSH2/3165 |
| Purity | Protein A/G affinity |
| UniProt | P43246 |
| Localization | Nucleus |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This MutS homolog 2 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
MutS homolog 2 (MSH2) is a nuclear DNA mismatch repair protein encoded by the MSH2 gene and functions as a central component of the mismatch repair pathway responsible for maintaining genomic integrity. MutS homolog 2 Antibody (clone MSH2/3165) recognizes MutS homolog 2 / MSH2 and supports detection of this essential DNA repair protein in studies examining genomic stability, DNA replication fidelity, and tumor biology. MSH2 forms heterodimeric complexes with other mismatch repair proteins, including MSH6 and MSH3, allowing recognition and correction of base-base mismatches and insertion-deletion loops generated during DNA replication.
MutS homolog 2 antibody, also referred to as MSH2 antibody or hMSH2 antibody in the literature, detects a nuclear protein that participates directly in DNA mismatch repair complexes. Within the nucleus, MSH2 acts as a recognition factor that initiates repair of mismatched DNA by recruiting additional proteins required for excision and resynthesis of damaged strands. Because this repair mechanism protects cells from mutation accumulation, MSH2 expression is widely studied in investigations of genomic maintenance and cancer development.
Alterations in MSH2 expression or function can lead to defects in mismatch repair pathways, resulting in increased mutation rates and microsatellite instability. Loss of MSH2 activity has been strongly associated with hereditary cancer syndromes such as Lynch syndrome and is also observed in certain sporadic tumors. As a result, detection of MSH2 protein expression is frequently used to investigate DNA repair deficiency, tumor biology, and genomic instability in research studies of cancer and cell cycle regulation.
MutS homolog 2 Antibody (clone MSH2/3165) enables analysis of MSH2 expression and localization in biological samples where mismatch repair activity and genomic stability are under investigation. Identification of MSH2-positive cells can provide insight into DNA repair pathway integrity and cellular responses to genomic damage. This mouse monoclonal antibody provides a reliable reagent for research examining mismatch repair proteins, genome maintenance mechanisms, and tumor-associated alterations in DNA repair pathways.
Optimal dilution of the MutS homolog 2 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the MutS homolog 2 antibody.
Aliquot the MutS homolog 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
MSH2 antibody, DNA mismatch repair protein MSH2 antibody, hMSH2 antibody, MSH2 mismatch repair antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
