- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Mucin 4 Antibody / MUC4 [clone MUCN4-1] (V7573)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7573-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7573-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7573SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V7573IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | MUCN4-1 |
| Purity | Protein G affinity chromatography |
| UniProt | Q99102 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This Mucin 4 antibody is available for research use only. |
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Mucin 4 antibody targets Mucin 4, a large transmembrane glycoprotein encoded by the human MUC4 gene and a member of the membrane-bound mucin family. Mucin 4, also commonly referred to as MUC4 in the literature, is primarily localized to the apical surface of epithelial cells where it contributes to mucosal protection and epithelial cell signaling. Mucin 4 antibody is widely used in studies of epithelial differentiation and tumor biology because MUC4 is frequently overexpressed and aberrantly regulated in multiple carcinomas.
MUC4 is synthesized as a high molecular weight precursor that undergoes proteolytic processing into two subunits that remain associated at the cell surface. The extracellular domain contains tandem repeat regions that are heavily O-glycosylated, forming a protective mucin barrier on epithelial surfaces. In normal tissues, Mucin 4 expression is largely restricted to glandular and ductal epithelia, including respiratory and gastrointestinal mucosa. In malignant transformation, however, MUC4 expression is often upregulated and loses normal polarity, contributing to tumor progression and altered cell-cell interactions. Mucin 4 antibody is therefore valuable for investigating epithelial tumor development and differentiation status.
MUC4 has also been shown to interact with receptor tyrosine kinases such as ERBB2, modulating downstream signaling pathways involved in proliferation, survival, and metastasis. Elevated MUC4 expression has been documented in pancreatic, breast, lung, and ovarian carcinomas, where it may correlate with aggressive disease and poor prognosis. Because of its functional involvement in oncogenic signaling, Mucin 4 antibody is frequently applied in cancer research and tumor characterization studies.
Structurally, Mucin 4 contains an extensive extracellular mucin domain with tandem repeats, multiple epidermal growth factor-like domains, a transmembrane region, and a cytoplasmic tail involved in intracellular signaling. A Mucin 4 antibody is suitable for detecting MUC4 expression in epithelial tissues and carcinoma research applications.
Optimal dilution of the Mucin 4 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Amino acids 1730-1864 from the human protein were used as the immunogen for this Mucin 4 antibody.
Store the Mucin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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