- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Mucin 1 Antibody / MUC1 [clone MUC1/7797R] (V4748)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4748-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4748-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4748SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MUC1/7797R |
| Purity | Protein A/G affinity |
| UniProt | P15941 |
| Localization | Cytoplasm, Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Mucin 1 antibody is available for research use only. |
|
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MuMucin 1 antibody targets Mucin 1, a transmembrane glycoprotein encoded by the human MUC1 gene and a member of the membrane-bound mucin family. Mucin 1, also widely referred to as MUC1 and epithelial membrane antigen in the literature, is primarily localized to the apical surface of epithelial cells where it contributes to barrier function and cell signaling. Mucin 1 antibody is commonly used in studies of epithelial biology and tumor progression due to the protein's characteristic overexpression and altered glycosylation in many carcinomas.
MUC1 is synthesized as a large precursor protein that undergoes autocatalytic cleavage into two subunits that remain non-covalently associated at the cell surface. The extracellular domain contains variable number tandem repeats that are heavily O-glycosylated, forming a protective mucous barrier. In normal tissues, Mucin 1 expression is restricted to the apical surface of glandular and ductal epithelia. In cancer, however, MUC1 is frequently overexpressed, loses apical polarity, and becomes aberrantly glycosylated, exposing peptide epitopes and contributing to oncogenic signaling. Mucin 1 antibody is therefore valuable for investigating epithelial transformation and tumor-associated antigen expression.
MUC1 participates in intracellular signaling through its cytoplasmic tail, interacting with beta-catenin and other signaling mediators to influence proliferation, apoptosis resistance, and metastatic behavior. Elevated MUC1 expression has been documented in breast, ovarian, pancreatic, lung, and colorectal carcinomas, where it is associated with tumor aggressiveness and poor prognosis. Because of its widespread clinical relevance, Mucin 1 antibody is frequently applied in oncology research and tumor characterization studies.
Structurally, Mucin 1 contains an extracellular mucin domain with tandem repeats, a transmembrane region, and a short cytoplasmic tail involved in signal transduction. A Mucin 1 antibody is suitable for detecting MUC1 expression in epithelial tissues, carcinoma models, and tumor biology research applications.
Optimal dilution of the Mucin 1 antibody should be determined by the researcher.
Recombinant full-length human MUC1 protein was used as the immunogen for the Mucin 1 antibody.
Aliquot the Mucin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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