- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MUC5AC Antibody / Mucin 5AC [clone MUC5AC/8340R] (V4161)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4161-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4161-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4161SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MUC5AC/8340R |
| Purity | Protein A/G affinity |
| UniProt | P98088 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This MUC5AC antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
MUC5AC antibody targets Mucin 5AC, a secreted gel-forming mucin encoded by the human MUC5AC gene and a member of the secreted mucin family. Mucin 5AC, also widely referred to as MUC5AC in the literature, is primarily expressed in gastric foveolar epithelium and mucus-secreting epithelial cells of the respiratory tract. MUC5AC antibody is commonly used in studies of gastric differentiation, mucosal biology, and tumor pathology because Mucin 5AC is a key component of the protective mucus barrier in the stomach and is frequently dysregulated in gastrointestinal and pulmonary diseases.
MUC5AC is synthesized as a large secreted glycoprotein characterized by extensive O-glycosylation and polymerization into high molecular weight mucin gels. In normal gastric tissue, Mucin 5AC is localized to the apical cytoplasm and secretory granules of surface foveolar cells, contributing to formation of the viscoelastic mucus layer that protects the epithelium from acid and enzymatic injury. In pathological conditions, including chronic gastritis, intestinal metaplasia, and gastric carcinoma, MUC5AC expression patterns may become altered. MUC5AC antibody is therefore valuable for evaluating gastric epithelial differentiation and mucin phenotype shifts in disease.
Beyond the stomach, aberrant Mucin 5AC expression has been reported in pancreatic, ovarian, lung, and colorectal carcinomas, where it may serve as a marker of mucinous differentiation. Elevated MUC5AC expression has also been observed in airway inflammatory conditions such as asthma and chronic obstructive pulmonary disease, reflecting its role in mucus hypersecretion.
Structurally, Mucin 5AC contains large tandem repeat domains rich in serine and threonine residues that support extensive glycosylation, as well as cysteine-rich domains that mediate mucin polymerization. A MUC5AC antibody is suitable for detecting Mucin 5AC expression in gastric epithelium, respiratory mucosa, and mucinous tumors in research applications.
Optimal dilution of the MUC5AC antibody should be determined by the researcher.
Recombinant full-length human MUC5AC protein was used as the immunogen for the MUC5AC antibody.
Aliquot the MUC5AC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(8)