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The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18 / CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MUC18 antibody to be titered up or down for optimal performance.
Recombinant human protein was used as the immunogen for this MUC18 antibody.
Store the MUC18 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Cell Surface Glycoprotein MUC18, Cell Surface Glycoprotein P1H12, Gicerin, MCAM, Melanoma Adhesion Molecule, Melanoma Associated Glycoprotein MUC18, Melanoma Cell Adhesion Molecule, Melanoma-associated Antigen A32, Mel-CAM, S-endo 1 Endothelial-associated Antigen, Sendo1, CD146 antibody
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