- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MUC16 Antibody Mouse Monoclonal [clone OCA125/1900] (V8373)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8373-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V8373-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8373SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | OCA125/1900 |
| Purity | Protein G affinity chromatography |
| UniProt | Q8WXI7 |
| Localization | Cell surface, cytoplasmic, secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This MUC16 antibody is available for research use only. |
|
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MUC16 Antibody recognizes Mucin 16 (MUC16), a very high molecular weight transmembrane glycoprotein widely known as CA125. MUC16 is a member of the membrane-associated mucin family and is characterized by extensive O-linked glycosylation, multiple tandem repeat domains, and a large extracellular region that can be shed into circulation. The MUC16 Antibody is useful for detecting epithelial MUC16 expression in research applications involving normal and neoplastic tissues.
MUC16 antibody, also referred to as CA125 antibody and Ovarian cancer antigen 125 antibody in the literature, targets a mucin primarily expressed on the apical surface of epithelial cells in the female reproductive tract, including endometrium and fallopian tube, as well as in ocular and respiratory epithelium. In physiologic settings, MUC16 contributes to epithelial barrier integrity, lubrication, and protection from pathogens and mechanical stress. Its extracellular domain can be cleaved and released, forming the basis of the clinically utilized CA125 serum biomarker.
The MUC16 gene is located on human chromosome 19p13.2 and encodes one of the largest cell surface proteins identified. Structurally, the protein contains numerous SEA domains, extensive tandem repeat regions, a transmembrane segment, and a short cytoplasmic tail involved in intracellular signaling. MUC16 has been shown to interact with mesothelin and other molecules that facilitate cell adhesion and metastatic spread, particularly in ovarian carcinoma.
Aberrant overexpression of MUC16 is most strongly associated with epithelial ovarian carcinoma and is also observed in subsets of endometrial, pancreatic, breast, and lung carcinomas. In histologic sections, MUC16 typically demonstrates apical membranous and cytoplasmic staining in positive epithelial tumor cells. A MUC16 antibody is commonly used in research settings to study epithelial differentiation, tumor biology, and mucin-related mechanisms in cancer progression. Clone OCA125/1900 is a mouse monoclonal antibody developed to target MUC16 in experimental systems.
Optimal dilution of the MUC16 antibody should be determined by the researcher.
Full length native MUC16 protein purified from human ovarian carcinoma was used as the immunogen for the MUC16 antibody.
Store the MUC16 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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