- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MUC1 Antibody / Mucin-1 [clone MUC1/8109R] (V4747)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4747-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4747-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4747SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MUC1/8109R |
| Purity | Protein A/G affinity |
| UniProt | P15941 |
| Localization | Cytoplasm, Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This MUC1 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
MUC1 antibody targets Mucin-1, a transmembrane glycoprotein encoded by the human MUC1 gene and a prominent member of the membrane-bound mucin family. Mucin-1, also widely referred to as MUC1 and epithelial membrane antigen in the literature, is primarily localized to the apical surface of epithelial cells where it contributes to barrier protection and cell signaling. MUC1 antibody is frequently used in studies of epithelial differentiation and carcinoma biology because Mucin-1 is characteristically overexpressed and aberrantly glycosylated in many epithelial malignancies.
MUC1 is synthesized as a large precursor that undergoes autocatalytic cleavage into two subunits that remain non-covalently associated at the cell surface. Its extracellular domain contains tandem repeat sequences that are extensively O-glycosylated, forming a protective mucin layer. In normal tissues, Mucin-1 expression is polarized to the apical membrane of glandular and ductal epithelial cells. In cancer, however, MUC1 often loses apical restriction, becomes diffusely expressed across the cell surface, and exhibits altered glycosylation patterns that expose core peptide epitopes. MUC1 antibody is therefore valuable for investigating tumor-associated antigen expression and epithelial transformation.
The cytoplasmic tail of Mucin-1 participates in intracellular signaling by interacting with beta-catenin and other regulatory proteins, influencing proliferation, apoptosis resistance, and metastatic potential. Elevated MUC1 expression has been documented in breast, ovarian, pancreatic, lung, and colorectal carcinomas, where it is frequently associated with aggressive disease. Because of its diagnostic and biological relevance, MUC1 antibody is widely applied in cancer research and tumor characterization studies.
Structurally, Mucin-1 consists of an extracellular mucin domain with variable number tandem repeats, a transmembrane region, and a short cytoplasmic tail involved in signal transduction. A MUC1 antibody is suitable for detecting Mucin-1 expression in epithelial tissues, carcinoma models, and tumor biology research applications.
Optimal dilution of the MUC1 antibody should be determined by the researcher.
Recombinant full-length human MUC1 protein was used as the immunogen for the MUC1 antibody.
Aliquot the MUC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(8)