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Home >> Antibodies >> MTF1 Antibody / Metal regulatory transcription factor 1

MTF1 Antibody / Metal regulatory transcription factor 1 [clone MTF1/2649] (V7966)

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  Catalog No Formulation Size Price (USD)  
Image V7966-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7966-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7966SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human renal cell carcinoma with MTF1 antibody (clone MTF1/2649). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human renal cell carcinoma with MTF1 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free MTF1 antibody as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name MTF1/2649
Purity Protein G affinity chromatography
UniProt Q14872
Localization Nuclear, cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This MTF1 antibody is available for research use only.
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Description

The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

Application Notes

Optimal dilution of the MTF1 antibody should be determined by the researcher.

Immunogen

A recombinant full-length human protein was used as the immunogen for the MTF1 antibody.

Storage

Store the MTF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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