- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MT-ND3 Antibody / NADH-ubiquinone oxidoreductase chain 3 Antibody (FY13568)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13568 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Species Reactivity | Human, Mouse |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Buffer | Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4. |
| UniProt | P03897 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | Intended solely for research purposes, this MT-ND3 Antibody / NADH-ubiquinone oxidoreductase chain 3 Antibody is not for clinical use. |
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MT-ND3 Antibody / NADH-ubiquinone oxidoreductase chain 3 Antibody detects MT-ND3, a mitochondrial DNA-encoded subunit of NADH:ubiquinone oxidoreductase, commonly called respiratory-chain complex I. Complex I is a large multisubunit enzyme embedded in the inner mitochondrial membrane. It transfers electrons from NADH to ubiquinone and couples this reaction to proton translocation, helping establish the electrochemical gradient used for ATP synthesis. MT-ND3 is one of the hydrophobic membrane-arm subunits encoded by the mitochondrial genome and is integrated into the assembled complex rather than acting as a soluble enzyme.
Complex I contains numerous nuclear-encoded accessory and core proteins in addition to its mitochondrially encoded subunits. The membrane arm mediates proton-pumping processes that are coupled to electron transfer through the peripheral arm. MT-ND3 contributes to the membrane architecture and conformational changes required for the complex to operate. A conserved cysteine in the ND3 subunit has received attention because its accessibility can change during transitions between active and deactive states of complex I. This structural behavior provides insight into how respiratory activity responds to changing metabolic conditions. The NADH-ubiquinone oxidoreductase chain 3 Antibody designation refers to this same molecular target.
Variants affecting MT-ND3 can impair complex I function and have been associated with mitochondrial disease, including neurological manifestations in some affected individuals. Interpretation of mitochondrial variants requires attention to heteroplasmy, tissue distribution, and the wider mitochondrial genetic background. MT-ND3 should also be distinguished from the similarly named nuclear genes encoding other NADH dehydrogenase components. NSJ Bioreagents includes MT-ND3 among its targets associated with mitochondrial electron transport and respiratory-chain organization. An MT-ND3 Antibody provides a way to investigate the biological role of MT-ND3 and the molecular processes associated with this target.
Explore related research targets in our Metabolism Antibody / Metabolism Antibodies collection.
The appropriate working dilution of the MT-ND3 Antibody / NADH-ubiquinone oxidoreductase chain 3 Antibody should be optimized by the end user.
The MT-ND3 Antibody was generated using a synthetic peptide corresponding to a sequence at the C-terminus of human ND3/MT-ND3.
Following reconstitution, the MT-ND3 Antibody can be kept at 4oC for one month. Aliquot for extended storage at -20oC for up to six months, avoiding repeated freezing and thawing.
MT-ND3 antibody, NADH-ubiquinone oxidoreductase chain 3 antibody, mitochondrially encoded NADH dehydrogenase 3 antibody, MT ND3 antibody, MTND3 antibody, NADH dehydrogenase subunit 3 antibody, NADH3 antibody, ND3 antibody
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