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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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MST1 Antibody recognizes macrophage stimulating protein (MSP), a secreted signaling protein encoded by the MST1 gene. Also known as hepatocyte growth factor-like protein, MSP belongs to the plasminogen-related growth factor family and functions as the primary ligand for the RON receptor tyrosine kinase, encoded by MST1R. The MSP-RON signaling pathway regulates cellular migration, adhesion, survival, and inflammatory responses. MST1 should not be confused with mammalian STE20-like kinase 1, a distinct serine/threonine kinase encoded by the STK4 gene.
The human MST1 gene is located on chromosome 3 and encodes a precursor protein of approximately 711 amino acids. MSP contains an N-terminal hairpin domain, four kringle domains, and a C-terminal serine protease-like domain. Although structurally related to proteolytic enzymes, MSP lacks conventional serine protease activity. The protein is synthesized as an inactive single-chain precursor that undergoes proteolytic processing to generate an alpha chain and a beta chain linked by disulfide bonds. This processing is necessary for efficient activation of the RON receptor.
Macrophage stimulating protein was originally identified through its ability to influence macrophage morphology and motility. Binding of mature MSP to RON promotes receptor dimerization and autophosphorylation, activating downstream signaling pathways that include PI3K-AKT, MAPK-ERK, and other regulators of cellular behavior. These signaling events influence epithelial cell migration, tissue remodeling, and responses to injury. The Macrophage Stimulating Protein Polyclonal Antibody is relevant to investigations of this ligand-receptor signaling system.
MSP-RON signaling also contributes to the regulation of innate immune responses. Depending on cellular context, RON activation can modify macrophage inflammatory activity and influence cytokine production. The pathway has been investigated in wound healing, epithelial regeneration, and inflammatory disease. Abnormal RON signaling is additionally associated with several malignancies, where it may contribute to tumor cell survival, migration, and invasive behavior.
Research involving MST1 frequently examines the relationship between growth factor processing, receptor activation, and downstream cellular responses. Distinguishing MSP from the unrelated STK4 kinase is particularly important when interpreting antibody data and gene expression studies. NSJ Bioreagents offers antibodies for investigating these signaling mechanisms. An MST1 Antibody provides a research tool for studying macrophage stimulating protein expression and its involvement in RON-dependent signaling, inflammation, and tissue homeostasis.
Explore our Signal Transduction Antibodies collection for additional antibodies targeting growth factors, receptors, and intracellular signaling proteins involved in cellular communication.
Titration of the MST1 Antibody / Macrophage Stimulating Protein Polyclonal Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 454-483 from the human protein was used as the immunogen for this MST1 antibody.
Aliquot the MST1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Macrophage Stimulating Protein antibody, MSP antibody, Hepatocyte Growth Factor-like Protein antibody, Macrophage Stimulating Protein 1 antibody, MST1 Polyclonal antibody
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