- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MSRA Antibody / Methionine sulfoxide reductase A (FY12909)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12909 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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MSRA antibody detects Methionine sulfoxide reductase A, a key antioxidant enzyme that repairs oxidized methionine residues in proteins, restoring their function and protecting cells from oxidative stress. Encoded by the MSRA gene on chromosome 8p23.1, this enzyme belongs to the methionine sulfoxide reductase family and plays an essential role in maintaining protein integrity and cellular redox balance. By catalyzing the reduction of methionine-S-sulfoxide back to methionine, MSRA reverses oxidative damage caused by reactive oxygen species (ROS).
Structurally, MSRA is a 235-amino-acid protein of approximately 26 kilodaltons containing a thioredoxin-like catalytic domain with a conserved cysteine residue essential for redox cycling. It exists in multiple isoforms localized to cytosolic, mitochondrial, and peroxisomal compartments, ensuring broad cellular protection. The enzyme utilizes thioredoxin as an electron donor, enabling reduction of oxidized methionine residues in structural and metabolic proteins.
The MSRA antibody is widely used in oxidative stress, neurodegeneration, and aging research to study redox regulation, protein repair, and cellular stress defense. Western blot analysis detects a 26 kilodalton band corresponding to MSRA, while immunofluorescence shows strong cytoplasmic and mitochondrial staining. This antibody provides a powerful tool for analyzing antioxidant defense systems and understanding how methionine oxidation influences cellular resilience and disease processes.
Functionally, MSRA contributes to cellular longevity by maintaining the functionality of oxidatively damaged proteins, particularly in mitochondria where ROS production is high. It has been implicated in protecting against neurodegenerative disorders, cardiovascular diseases, and metabolic stress. Loss of MSRA activity accelerates protein oxidation and mitochondrial dysfunction, whereas its overexpression enhances stress tolerance and lifespan in model organisms. The MSRA antibody supports research into oxidative repair mechanisms, antioxidant therapeutics, and the molecular basis of redox regulation. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and immunofluorescence, ensuring accuracy in studies of protein oxidation and repair.
Optimal dilution of the MSRA antibody should be determined by the researcher.
E.coli-derived mouse MSRA recombinant protein (Position: M1-D215) was used as the immunogen for the MSRA antibody.
After reconstitution, the MSRA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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