- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MSLNL Antibody / Mesothelin-Like Protein Antibody recognizes MSLNL, a human mesothelin-related protein also known as MPFL and C16orf37. MSLNL is a 702-amino acid protein with sequence similarity to members of the mesothelin family and is also known as pre-pro-megakaryocyte-potentiating-factor-like protein. MSLNL is associated with predicted cell-surface and cell-matrix adhesion functions, although its biological role remains poorly characterized. This makes the protein of interest for studies investigating mesothelin-related proteins, cell adhesion and cell-surface protein expression.
MSLNL shares evolutionary and sequence relationships with MSLN, the gene encoding mesothelin. Mesothelin itself is synthesized as a precursor that undergoes proteolytic processing to generate megakaryocyte potentiating factor and a cell-surface mesothelin protein. Although this relationship provides biological context for MSLNL, the functions established for mesothelin should not automatically be attributed to Mesothelin-Like Protein. UniProt currently assigns MSLNL protein existence based on homology and describes a possible role in cellular adhesion by similarity, indicating that its functional characterization remains substantially less developed than that of MSLN.
Current Gene Ontology annotations associate MSLNL with cell-matrix adhesion and provide a framework for investigating its possible relationship with cell-surface and extracellular biology. These annotations are prediction-based rather than evidence of a thoroughly characterized human biological function. An MSLNL Antibody can therefore be useful in experimental studies aimed at examining the presence, distribution or molecular characteristics of the proposed Mesothelin-Like Protein and evaluating predicted aspects of its biology.
The MSLNL locus is located on human chromosome 16p13.3 and has historically been designated C16orf37. MPFL is another established synonym reflecting its relationship to the megakaryocyte potentiating factor/mesothelin protein family. Comparative studies are particularly relevant to this target because MSLNL orthologs in other vertebrates retain protein-coding annotations. Mouse Mslnl, for example, encodes a mesothelin-like protein precursor containing a conserved mesothelin domain and is predicted to participate in cell-matrix adhesion at the cell surface.
MSLNL remains a relatively poorly characterized member of the broader mesothelin-related protein family, providing opportunities to investigate its expression and potential molecular properties experimentally. Its relationship to mesothelin, predicted association with cell-matrix adhesion and historical MPFL designation make it relevant to studies of cell-surface proteins and mesothelin family biology. NSJ Bioreagents supplies antibodies to MSLNL and other proteins associated with cell adhesion and membrane biology. An MSLNL Antibody can support research on Mesothelin-Like Protein expression, MPFL, cell-surface biology and mesothelin-related proteins.
For related targets involved in cell-surface biology, cellular interactions and protein function, explore our Cell Biology Antibodies page.
Optimal dilution of the MSLNL Antibody / Mesothelin-Like Protein Antibody should be determined by the researcher.
An E.coli-derived human recombinant protein (Q65-H423) was used as the immunogen for the MSLNL antibody.
After reconstitution, the MSLNL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
MSLNL antibody, Mesothelin-like protein antibody, MPFL antibody, C16orf37 antibody, Pre-pro-megakaryocyte-potentiating-factor-like antibody
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