- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MRP3 Antibody Rabbit Polyclonal / Multidrug resistance-associated protein 3 (RQ8175)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8175 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | O15438 |
| Applications | Western Blot : 0.5-1ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This MRP3 antibody is available for research use only. |
|
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MRP3 antibody recognizes Multidrug resistance-associated protein 3, a transmembrane efflux transporter encoded by the ABCC3 gene. Also known as ATP-binding cassette subfamily C member 3 and ABCC3, MRP3 belongs to the ABC transporter family and functions as an ATP-dependent export pump for organic anions and conjugated metabolites. MRP3 antibody is widely used in research investigating hepatobiliary transport, xenobiotic clearance, and mechanisms of multidrug resistance.
MRP3 is predominantly localized to the basolateral membrane of hepatocytes, as well as epithelial cells in the intestine, pancreas, and kidney. Structurally, ABCC3 contains two nucleotide-binding domains and multiple transmembrane helices typical of ABC transporters. The protein facilitates the export of glucuronide, sulfate, and glutathione conjugates, including bile acids and bilirubin metabolites, from cells into the bloodstream. In cholestatic conditions or when canalicular transporters are impaired, MRP3 expression is often upregulated as a compensatory mechanism to maintain bile acid homeostasis.
Altered ABCC3 expression has been reported in inflammatory liver disease, cholestasis, and several malignancies. Increased MRP3 levels have also been associated with resistance to certain chemotherapeutic agents due to enhanced drug efflux capacity. Immunostaining typically demonstrates membranous localization in epithelial tissues, consistent with its role as a plasma membrane transporter. This rabbit polyclonal MRP3 antibody is suitable for detecting ABCC3 in research applications focused on drug metabolism, transporter biology, and hepatic pathophysiology.
Optimal dilution of the MRP3 antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids H22-G1351) was used as the immunogen for the MRP3 antibody.
After reconstitution, the MRP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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