- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MPZ Antibody / Myelin Structural Protein Antibody [clone MPZ/7390] (V4754)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4754-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4754-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4754SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | MPZ/7390 |
| Purity | Protein A/G affinity |
| UniProt | P25189 |
| Localization | Membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This MPZ Antibody / Myelin Structural Protein Antibody is available for research use only. |
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MPZ Antibody / Myelin Structural Protein Antibody recognizes Myelin Protein Zero (MPZ, P0), the major structural protein of peripheral nervous system myelin. MPZ is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and functions as a critical adhesion molecule that mediates homophilic interactions between adjacent layers of the myelin sheath. Through these adhesive properties, MPZ promotes myelin compaction and structural stability, making it essential for efficient nerve conduction and long-term maintenance of peripheral nerve integrity.
MPZ Antibody is widely used for studying myelination, Schwann cell biology, and peripheral nervous system development. During nerve maturation, Schwann cells produce multilamellar myelin sheaths that insulate axons and facilitate rapid saltatory conduction. MPZ represents the most abundant protein component of peripheral myelin and serves as a key marker of myelin formation and maintenance. Expression of MPZ is therefore frequently examined in studies investigating nerve development, axon-glia interactions, and the molecular mechanisms that regulate myelin assembly.
MPZ Antibody is also valuable for research involving peripheral nerve injury and regeneration. Following nerve damage, Schwann cells undergo extensive phenotypic changes that support axonal repair and remyelination. Because proper restoration of myelin architecture is required for functional recovery, MPZ expression is commonly monitored as an indicator of Schwann cell differentiation and successful remyelination. Analysis of MPZ can provide important insights into regenerative processes and the restoration of peripheral nerve function following injury.
MPZ Antibody has significant relevance in the study of inherited neuropathies and demyelinating disorders. Mutations in the MPZ gene have been linked to several peripheral nerve diseases, including forms of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, and congenital hypomyelinating neuropathy. These disorders are characterized by abnormalities in myelin structure, impaired nerve conduction, and progressive neurological dysfunction. Consequently, MPZ remains an important biomarker for investigations of peripheral neuropathy pathogenesis and therapeutic development.
MPZ Antibody, clone MPZ/7390, supports research involving myelination, nerve development, Schwann cell differentiation, peripheral nerve regeneration, and neurological disease. Because MPZ occupies a central role in the formation and maintenance of compact myelin, it remains one of the most widely studied structural proteins of the peripheral nervous system and an important target for neuroscience and translational research.
Researchers studying myelination, Schwann cell biology, nerve development, and cell adhesion may also be interested in our comprehensive collection of Cell Biology Antibodies.
Optimal dilution of the MPZ Antibody / Myelin Structural Protein Antibody should be determined by the researcher.
Recombinant full-length human MPZ protein was used as the immunogen for the MPZ antibody.
Aliquot the MPZ antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
MPZ Antibody, Myelin Protein Zero Antibody, P0 Antibody, Myelin Structural Protein Antibody, Peripheral Myelin Protein Antibody, Myelin Adhesion Protein Antibody, Protein Zero Antibody, Major Peripheral Myelin Protein Antibody
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