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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MPO Antibody Mouse Monoclonal rMPO/8694 / Myeloperoxidase Antibody [clone rMPO/8694] (V4516)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4516-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4516-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4516SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rMPO/8694 |
| Purity | Protein A/G affinity |
| UniProt | P05164 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This MPO antibody is available for research use only. |
|
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Myeloperoxidase (MPO) is a heme-containing peroxidase enzyme encoded by the MPO gene and is highly abundant in the azurophilic granules of neutrophils. MPO is a key component of the innate immune system and participates in antimicrobial defense by generating reactive oxidant species during the respiratory burst of activated phagocytes. MPO Antibody Mouse Monoclonal rMPO/8694 recognizes Myeloperoxidase / MPO and supports detection of this enzyme in studies focused on neutrophil biology, inflammation, and myeloid lineage cell function. The enzyme catalyzes the conversion of hydrogen peroxide and chloride ions into hypochlorous acid, a potent oxidant that contributes to microbial killing within phagosomes.
Myeloperoxidase antibody, also referred to as MPO antibody or myeloid peroxidase antibody in the literature, detects a granule-associated enzyme that is strongly expressed in neutrophils and present in monocytes and early myeloid precursors. Because MPO expression is highly characteristic of granulocytic lineage cells, the protein is widely used as a marker for identifying neutrophils and analyzing inflammatory infiltrates in biological samples. MPO Antibody Mouse Monoclonal rMPO/8694 enables detection of MPO-positive cells in studies examining immune cell recruitment, infection responses, and inflammatory signaling pathways.
Within neutrophils, MPO is stored in cytoplasmic azurophilic granules and released during activation and degranulation. In addition to antimicrobial activity, MPO-derived oxidants influence inflammatory signaling and oxidative modification of proteins, lipids, and nucleic acids. These reactions contribute to immune regulation but may also play roles in tissue injury during chronic inflammatory conditions. Because of these functions, MPO has been widely studied in research areas including cardiovascular disease, autoimmune disorders, infection biology, and tumor-associated inflammation.
Detection of Myeloperoxidase using MPO Antibody Mouse Monoclonal rMPO/8694 allows researchers to identify granulocytic cells and evaluate neutrophil involvement in immune responses. Analysis of MPO expression can provide insight into inflammatory cell recruitment, granulocyte activation, and oxidative immune mechanisms in both normal physiology and disease. This mouse monoclonal antibody provides a useful reagent for research investigating innate immune biology, inflammatory disease mechanisms, and myeloid cell activity.
Optimal dilution of the MPO Antibody Mouse Monoclonal rMPO/8694 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 150-250) from the human protein was used as the immunogen for the MPO antibody.
Aliquot the MPO antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Myeloperoxidase antibody, MPO antibody, Myeloid peroxidase antibody, Neutrophil MPO antibody
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