- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MPO Antibody / Myeloperoxidase [clone MPO/7118] (V9354)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9354-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V9354-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
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V9354SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | MPO/7118 |
| Purity | Protein A/G affinity |
| UniProt | P05164 |
| Localization | Cytoplasm |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Myeloperoxidase antibody is available for research use only. |
|
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MPO antibody detects myeloperoxidase, an enzyme encoded by the MPO gene. Myeloperoxidase is abundantly expressed in neutrophil granules, where it catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride ions during the respiratory burst. Because MPO plays critical roles in antimicrobial defense, inflammation, and cardiovascular pathology, MPO antibody is widely used in immunology, pathology, and inflammation research.
Myeloperoxidase is a heme-containing enzyme that contributes to the microbicidal activity of neutrophils and monocytes. Its oxidative products damage pathogens but can also harm host tissues when dysregulated. Elevated MPO activity has been linked to chronic inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and neurodegeneration. In pathology, MPO staining is used to identify myeloid lineage cells and diagnose leukemias.
The MPO antibody clone MPO/7118 provides specific and reproducible recognition. Clone MPO/7118 has been cited in peer-reviewed studies examining oxidative stress, innate immunity, and cardiovascular disease. Its reproducibility makes it suitable for immunohistochemistry, Western blotting, and ELISA applications where accurate detection of MPO is needed.
Research using clone MPO/7118 has clarified how MPO contributes to vascular inflammation and plaque instability in atherosclerosis. In oncology, MPO detection aids in distinguishing myeloid leukemias from other hematologic malignancies. In immunology, MPO analysis has supported studies of host-pathogen interactions and mechanisms of innate defense. This antibody has also been applied in studies linking oxidative damage to tissue injury in neuroinflammatory conditions.
NSJ Bioreagents provides this MPO antibody to support immunology, oncology, and inflammation research. Alternate names include myeloperoxidase antibody, neutrophil peroxidase antibody, heme peroxidase antibody, azurophilic granule enzyme antibody, oxidative burst enzyme antibody, and MPO gene product antibody.
Optimal dilution of the Myeloperoxidase antibody should be determined by the researcher.
A recombinant protein fragment was used as the immunogen for the Myeloperoxidase antibody.
Aliquot the Myeloperoxidase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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