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Home >> Antibodies >> MMP9 Antibody / Matrix metalloproteinase-9

MMP9 Antibody / Matrix metalloproteinase-9 [clone SPM425] (V8238)

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  Catalog No Formulation Size Price (USD)  
Image V8238-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8238-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8238SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human spleen with MMP9 antibody (clone SPM425). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human spleen with MMP9 antibody (clone SPM425). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name SPM425
Purity Protein G affinity chromatography
UniProt P14780
Localization Cytoplasmic, nuclear, secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This MMP9 antibody is available for research use only.
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Description

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.

Application Notes

Optimal dilution of the MMP9 antibody should be determined by the researcher.

Immunogen

A recombinant human partial protein (amino acids 22-166) was used as the immunogen for this MMP9 antibody.

Storage

Store the MMP9 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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