- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MMP7 Antibody (R31468)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R31468 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| Gene ID | 4316 |
| Applications | Western blot : 0.5-1ug/ml IHC (FFPE) : 0.5-1ug/ml ELISA : 0.1-0.5ug/ml (human protein tested); request BSA free format for coating |
| Limitations | This MMP7 antibody is available for research use only. |
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Matrix metalloproteinase-7, previously called putative metalloproteinase I (PUMP1) or Matrilysin, has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The protein has 267 amino acids and is significantly shorter than stromelysin or collagenase (477 and 469 amino acids, respectively). Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. MMP7, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, mRNA is regulated in a specific and distinct manner in normal and malignant tissues. MMP7 has been shown to correlate with nodal or distant metastasis in colorectal carcinomas, however, its implication in early invasive colorectal carcinomas has not been determined. It is a mediator of pulmonary fibrosis and a potential therapeutic target.
The stated application concentrations are suggested starting amounts. Titration of the MMP7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human partial recombinant protein (AA 1-267) was used as the immunogen for this MMP7 antibody.
After reconstitution, the MMP7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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